Phosphorane, ethylidenetriphenyl- → Ethyl alpha-(3,4-dimethoxyphenyl)crotonate

HRID 616652

반응식

HRID 616652 반응식
[CH:1](=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:2].[CH3:22][O:23][C:24]1[CH:25]=[C:26]([C:32](=O)[C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH:27]=[CH:28][C:29]=1[O:30][CH3:31]>[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C.CCOCC>[CH3:22][O:23][C:24]1[CH:25]=[C:26](/[C:32](=[CH:1]\[CH3:2])/[C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH:27]=[CH:28][C:29]=1[O:30][CH3:31]

참가 물질

5

반응물 2

HCID 137195Phosphorane, ethylidenetriphenyl-HCID 170290Benzeneacetic acid, 3,4-dimethoxy-alpha-oxo-, ethyl ester

생성물 1

HCID 70615010Ethyl alpha-(3,4-dimethoxyphenyl)crotonate

시약·촉매·용매 2

HCID 73727Phosphonium, ethyltriphenyl-, bromide (1:1)촉매HCID 3283Diethyl Ether용매2회

실험 절차

To a diethyl ether solution of ethylidenetriphenylphosphorane prepared in the usual way from 800 g. of ethyltriphenylphosphonium bromide, 400 g. of ethyl 3,4-dimethoxyphenylglyoxylate in 600 ml. of ether are added dropwise. After refluxing for 4-5 hours, the solvent is evaporated and substituted with tetrahydrofuran. The mixture is then heated for 36 hours and then evaporated to dryness and the residue is extracted with diethyl ether in a Soxhlet apparatus giving 150 g. of the title compound. Pursuant to this procedure, the following other α-arylcrotonate starting materials are prepared:

후처리

  1. temperatureAfter refluxing for 4-5 hours
  2. customthe solvent is evaporated
  3. temperatureThe mixture is then heated for 36 hours
  4. customevaporated to dryness
  5. extractionthe residue is extracted with diethyl ether in a Soxhlet apparatus
  6. customgiving 150 g

출처 및 근거

ORD 기록
ord-a5755b4f3c46421b8a14187d27c854ba
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04075241

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