p-Toluenesulfonic acid monohydrate → HCID 20368829, 화합물

HRID 616706노트

반응식

HRID 616706 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:4]2[CH:3]=1.[OH2:20].[C:21]1(C)C=C[C:24](S(O)(=O)=O)=[CH:23][CH:22]=1>C(O)CCC>[CH2:21]([O:20][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:4]2[CH:3]=1)[CH2:22][CH2:23][CH3:24]

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 12763962HCID 12763962, 화합물

생성물 1

HCID 20368829HCID 20368829, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of ethyl 5-chloroimidazo[1,2-a]quinoline-2-carboxylate 2.75 g. (0.01 mole) and 40 mg. of p-toluenesulfonic acid monohydrate in 150 ml. of n-butanol is heated at 100° C. for 18 hours. The butanol is then removed under reduced pressure. The residue is dissolved in a small amount of chloroform and chromatographed on a silica gel column. The fractions containing the title compound are combined and evaporated to dryness. The product can be further purified by crystallization.

후처리

  1. customThe butanol is then removed under reduced pressure
  2. dissolutionThe residue is dissolved in a small amount of chloroform
  3. customchromatographed on a silica gel column
  4. additionThe fractions containing the title compound
  5. customevaporated to dryness
  6. customThe product can be further purified by crystallization

출처 및 근거

ORD 기록
ord-7b2c0e2c2dc34d0e8e496aecb0c4dd0a
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04075343

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