반응식
[F:1][C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1.[C:17](Cl)([Cl:19])=[O:18]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:17]([Cl:19])=[O:18])[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
A mixture of 2.3 g of 10-fluoro-5H-dibenz[b,f]azepine and 30 ml of toluene saturated with phosgene is stirred for 2 days at 25° C. Excess phosgene is then expelled with nitrogen and the reaction mixture is concentrated by rotary evaporation to yield crude 10-fluoro-5H-dibenz[b,f]azepine-5-carbonyl chloride as residue.
후처리
- concentrationthe reaction mixture is concentrated by rotary evaporation
출처 및 근거
- ORD 기록
- ord-84342a3214e94d54b38ef2410a598ec3
- 출처 데이터셋
- uspto-grants-1978_02
- 특허 번호
- US04076812
연결된 노트
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