1-Butanol → 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carboxylic acid, n-butyl ester
반응식
[O:1]=[C:2]1[N:11]2[N:12]=[C:13]([C:15](Cl)=[O:16])[CH:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.C([OH:22])CCC.N1C=[CH:27][CH:26]=[CH:25][CH:24]=1>>[O:1]=[C:2]1[N:11]2[N:12]=[C:13]([C:15]([O:16][CH2:24][CH2:25][CH2:26][CH3:27])=[O:22])[CH:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1참가 물질
4
실험 절차
To a suspension of 4.6 g (0.019 mole) of 5,6-dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carbonyl chloride in 200 ml of pyridine under nitrogen is added, slowly in a dropwise fashion, a solution of 1.98 g (0.019 mole) of n-butanol. After stirring overnight at room temperature, the reaction mixture is filtered and the filtrate concentrated to a small volume and diluted with cold water. The title compound is filtered off and dried, m.p. 198°-200°.