1-Bromooctane → 4'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

HRID 617115

반응식

HRID 617115 반응식
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.[OH-].[Na+]>>[CH2:1]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=[CH:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

4

반응물 3

HCID 81401-BromooctaneHCID 14798Sodium HydroxideHCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

생성물 1

HCID 28025564'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

반응 조건

온도
70 °C

실험 절차

n-Octyl bromide (0.102 mol) is added to a solution of 4-(4-hydroxyphenyl)benzoic acid (0.102 mol) and 2.5 N sodium hydroxide (0.102 mol) and the mixture stirred at 70° C. for a period of 18 hours. The reaction mixture is allowed to cool and then acidified to pH 3 and partitioned between ethyl acetate and water. The organic phase is washed with water and brine and the solvent then removed to obtain the 4'-n-octyloxy-[1,1'-biphenyl]-4-ylcarboxylic acid, C21H23O3, M.W. 326.4

후처리

  1. temperatureto cool
  2. custompartitioned between ethyl acetate and water
  3. washThe organic phase is washed with water and brine
  4. customthe solvent then removed

출처 및 근거

ORD 기록
ord-1b3a60408c6b4b91a7c7f2cdc4ed6e53
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05948753

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