P-Anisidine → 2-amino-N-(4-methoxy-phenyl)-3-methoxy-benzamide

HRID 617128노트

반응식

HRID 617128 반응식
[CH3:1][O:2][C:3]1[C:8]2[NH:9]C(O[C:13](=[O:14])[C:7]=2[CH:6]=[CH:5][CH:4]=1)=O.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=1>C(O)C.CN(C)C1C=CN=CC=1>[NH2:9][C:8]1[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=1[C:13]([NH:23][C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=1)=[O:14]

참가 물질

5

반응물 2

HCID 7732P-AnisidineHCID 105596798-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione

생성물 1

HCID 181744302-amino-N-(4-methoxy-phenyl)-3-methoxy-benzamide

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 702Ethanol용매

실험 절차

To a solution of 27.17 g (0.141 mol) of 8-methoxyisatoic anhydride in 200 mL of ethanol was added a catalytic amount of 4-dimethylaminopyridine and 350 mL of a 1M solution containing 43.0 g (0.350 mol) of p-anisidine. The reaction mixture was stirred and heated under reflux overnight. The reaction flask was then chilled on ice. The precipitate that formed was collected by vacuum filtration and amounted to 34.7 g. An analytical sample (mp 168-169° C.) was obtained by recrystallization from ethanol.

후처리

  1. temperatureheated
  2. temperatureunder reflux overnight
  3. temperatureThe reaction flask was then chilled on ice
  4. customThe precipitate that formed
  5. filtrationwas collected by vacuum filtration
  6. customAn analytical sample (mp 168-169° C.) was obtained by recrystallization from ethanol

출처 및 근거

ORD 기록
ord-f72bda8dcd30406794af07be74c69540
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05948775

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