Dopac → HCID 21851548, 화합물

HRID 617181

반응식

HRID 617181 반응식
[NH2:1][C:2]1[N:11]=[C:10]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[OH:18][C:19]1[CH:20]=[C:21]([CH2:26][C:27](O)=[O:28])[CH:22]=[CH:23][C:24]=1[OH:25]>CN(C)C1C=CN=CC=1.CN(C)C=O>[NH2:1][C:2]1[N:11]=[C:10]([CH:12]2[CH2:17][CH2:16][N:15]([C:27](=[O:28])[CH2:26][C:21]3[CH:22]=[CH:23][C:24]([OH:25])=[C:19]([OH:18])[CH:20]=3)[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

5

반응물 2

HCID 547DopacHCID 15428775HCID 15428775, 화합물

생성물 1

HCID 21851548HCID 21851548, 화합물수율 60.2%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6228Dimethylformamide용매

실험 절차

To an ice-cold solution of 2-amino-4-(4-piperidinyl)quinazoline (600 mg, 2.63 mmol) obtained in example 11(1), 3,4-dihydroxyphenylacetic acid (530 mg, 3.16 mmol) and 4-dimethylaminopyridine (386 mg, 3.16 mmol) in dimethylformamide (20 ml) was added 1-ethyl-3-(N,N'-dimethylaminopropyl)carbodiimide hydrochloride (605 mg, 3.16 mmol) under a nitrogen atmosphere. The mixture was stirred overnight at room temperature. The solvent was removed in vacuo and the residue was crystallized from methanol to give the titled compound (599 mg).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was crystallized from methanol

출처 및 근거

ORD 기록
ord-1a25b87a62d743c3ad64eaa5fa0c8dcd
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05948786

연결된 노트

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