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Hydrochloric Acid → 6,6-Dimethyl-11-oxo-8-(2-oxo-2-piperazin-1-yl-ethoxy)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloric acid salt

HRID 61726
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인쇄 미리보기

반응식

HRID 61726 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:39])[CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]3[C:32](=[O:33])[C:31]4[C:30]5[C:25](=[CH:26][C:27]([C:34]#[N:35])=[CH:28][CH:29]=5)[NH:24][C:23]=4[C:22]([CH3:37])([CH3:36])[C:21]=3[CH:38]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:40].O1CCOCC1>O>[ClH:40].[CH3:36][C:22]1([CH3:37])[C:23]2[NH:24][C:25]3[C:30](=[CH:29][CH:28]=[C:27]([C:34]#[N:35])[CH:26]=3)[C:31]=2[C:32](=[O:33])[C:20]2[CH:19]=[CH:18][C:17]([O:16][CH2:15][C:14](=[O:39])[N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:38][C:21]1=2
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668341864-[2-(3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yloxy)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 668341186,6-Dimethyl-11-oxo-8-(2-oxo-2-piperazin-1-yl-ethoxy)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloric acid salt

시약·촉매·용매 1

HCID 962
Water
용매

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온도
10 °C

실험 절차

4-[2-(3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yloxy)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester (Compound A9-15-1, 20 mg) was added with 4 N hydrochloric acid and dioxane solution (1 ml), and stirred in an water bath at 10° C. for 4 hr. Water was added to the reaction solution and the resulting precipitates were filtered and dried to obtain the title compound (15 mg, white powder).

후처리

  1. customthe resulting precipitates
  2. filtrationwere filtered
  3. customdried

출처 및 근거

ORD 기록
ord-ca07e01d83644f85b03bea49b56a6b0c
출처 데이터셋
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09440922B2

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