Hydrochloric Acid → 6-(Morpholine-4-carbonyl)nicotinic acid
반응식
[N:1]1([C:7]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([O:15]C(C)(C)C)=[O:14])=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl>[N+](C)([O-])=O>[N:1]1([C:7]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1참가 물질
4
실험 절차
In step c, the t-butyl ester functionality of 16 is hydrolyzed, with for example, HCl in nitromethane, to give the corresponding 6-(morpholine-4-carbonyl)nicotinic acid 17.
출처 및 근거
- ORD 기록
- ord-de85fe32639e46ed8a70409429658c3a
- 출처 데이터셋
- uspto-grants-1999_09
- 특허 번호
- US05948886
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