Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 617633노트

반응식

HRID 617633 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[CH2:11]([OH:13])[CH3:12]>>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:13][CH2:11][CH3:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 145174-Fluorobenzonitrile

생성물 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride

실험 절차

Ethyl 4-fluorobenzimidate hydrochloride was synthesized in the same manner as in Reference Example 2. That is, 4-fluorobenzonitrile (50.8 g, 0.407 mol) was treated with hydrogen chloride in ethanol (500 mL) to give 82.1 g (99%) of the target compound as colorless crystals.

출처 및 근거

ORD 기록
ord-96886884dc384d9bb54569d995d1b8b5
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05948785

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