Phthalic Anhydride → 2-(6-hydroxyhexyl)-2,3-dihydro-1H-isoindole-1,3-dione

HRID 617715노트

반응식

HRID 617715 반응식
[C:1]1(=[O:18])[N:5]([CH:6](C)[CH2:7][CH2:8][CH2:9][CH2:10]O)[C:4](=[O:13])[C:3]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:2]12.NCCCCC[CH2:25][OH:26].C1(=O)OC(=O)C2=CC=CC=C12>>[C:4]1(=[O:13])[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:25][OH:26])[C:1](=[O:18])[C:2]2=[CH:17][CH:16]=[CH:15][CH:14]=[C:3]12

참가 물질

4

반응물 3

HCID 6811Phthalic AnhydrideHCID 199606-Amino-1-hexanolHCID 127813485-Phthalimidohexanol

생성물 1

HCID 129502192-(6-hydroxyhexyl)-2,3-dihydro-1H-isoindole-1,3-dione수율 91%

실험 절차

This compound was prepared in the same manner as 5-phthalimidohexanol from 6-aminohexanol (3.51 g, 30.0 mmol) and phthalic anhydride (4.44 g, 30.0 mmol) to give the product as brown oil: yield 91%; 1H NMR (CDCl3) δ 1.3-1.8 (m, 8H), 3.6-3.7 (m, 4H), 4.3 (t, J=6.5 Hz, 1H), 7.7 (m, 2H), 7.8 (m, 2H).

출처 및 근거

ORD 기록
ord-94ff5347b5c24f60b32c4bbfe3402c6a
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952307

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