1-Bromoundecane → 3-(3-Undecyloxyphenyl)propanol

HRID 617843노트

반응식

HRID 617843 반응식
[OH-].[Na+].[CH2:3](Br)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[OH:15][C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][CH2:24][OH:25])[CH:19]=[CH:20][CH:21]=1>C(O)C>[CH2:3]([O:15][C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][CH2:24][OH:25])[CH:19]=[CH:20][CH:21]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 127441-BromoundecaneHCID 14798Sodium HydroxideHCID 103518713-Hydroxybenzenepropanol

생성물 1

HCID 218493913-(3-Undecyloxyphenyl)propanol수율 80.3%

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
70 °C

실험 절차

A 15 N aqueous sodium hydroxide solution (2 ml) and a solution (10 ml) of 8.0 g of undecyl bromide in ethanol was added to a solution (30 ml) of 4.56 g of 3-(3-hydroxyphenyl)propanol in ethanol and the mixture was stirred at 70° C. for 12 hours. The solvent was distilled away and the residue was extracted with ethyl acetate. The extract was washed with saturated sodium hydrogencarbonate and brine, and dried over magnesium sulfate. The solvent was distilled away and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:20-1:3) to give 7.37 g of 3-(3-undecyloxyphenyl)propanol as a colorless, oily substance.

후처리

  1. distillationThe solvent was distilled away
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe extract was washed with saturated sodium hydrogencarbonate and brine
  4. dry with materialdried over magnesium sulfate
  5. distillationThe solvent was distilled away
  6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:20-1:3)

출처 및 근거

ORD 기록
ord-e0f8219bd03d4a219f95efeed23daeb0
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952316

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