3',4',5'-Trimethoxyacetophenone → (E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one

HRID 618114

반응식

HRID 618114 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13](=[O:15])[CH3:14])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH3:16][O:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22]([CH:27]=O)=[CH:23][NH:24]2)=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22](/[CH:27]=[CH:14]/[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)=[O:15])=[CH:23][NH:24]2)=[CH:20][CH:19]=1

참가 물질

3

반응물 2

HCID 143453',4',5'-TrimethoxyacetophenoneHCID 9072146-Methoxy-1H-indole-3-carboxaldehyde

생성물 1

HCID 21850283(E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one수율 32%

실험 절차

Substantially the same procedure as in Example 1 was repeated using 3',4',5'-trimethoxyacetophenone (659 mg) and 6-methoxyindole-3-carboxaldehyde (550 mg) except that the reaction solution was concentrated under reduced pressure, that the residue was purified by silica gel column chromatography, and that the obtained crude crystals were recrystallized from ethanol, to give Compound 39 (369 mg).

후처리

  1. concentrationwas concentrated under reduced pressure, that the residue
  2. customwas purified by silica gel column chromatography
  3. customthat the obtained crude crystals
  4. customwere recrystallized from ethanol

출처 및 근거

ORD 기록
ord-f3c262c37ecd43e0955d3e99bad2ecf7
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952355

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