Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → (E)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Indole-3-Carboxaldehyde | HCID 10256 | — |
| 반응물 | Acetosyringone | HCID 17198 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (E)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one | HCID 21850208 | 19.2% |
반응 단계
4'-Hydroxy-3',5'-dimethoxyacetophenone (1.96 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 32 hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography. The obtained crude crystals were recrystallized from ethyl acetate to give Compound 70 (0.62 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952355 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-74a841b976bc4f10a9a9ce9d1f52035d |
| 출처 메모 | uspto-grants-1999_09 |