反应详情

4'-Hydroxy-3',5'-dimethoxyacetophenone (1.96 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 32 hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography. The obtained crude crystals were recrystallized from ethyl acetate to give Compound 70 (0.62 g).

1. temperatureby heating
2. temperatureunder reflux for 32 hours
3. concentrationThe reaction solution was concentrated under reduced pressure
4. customthe residue was purified by silica gel column chromatography
5. customThe obtained crude crystals
6. customwere recrystallized from ethyl acetate