Piperidine → 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one

HRID 618131

반응식

HRID 618131 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11](=[O:13])[CH3:12].[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([CH:23]=O)=[CH:15]1.N1CCCCC1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11](=[O:13])[CH:12]=[CH:23][C:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 10256Indole-3-CarboxaldehydeHCID 709912',5'-Dimethoxyacetophenone

생성물 1

HCID 541569131-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one수율 44%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2',5'-Dimethoxyacetophenone (1.80 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 72 hours. The precipitated crystals were collected by filtration, and the obtained crude crystals were recrystallized from ethanol to give Compound 89 (1.35 g).

후처리

  1. temperatureby heating
  2. temperatureunder reflux for 72 hours
  3. filtrationThe precipitated crystals were collected by filtration
  4. customthe obtained crude crystals
  5. customwere recrystallized from ethanol

출처 및 근거

ORD 기록
ord-05fe39220067459285c6760684758e9b
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952355

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