Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Indole-3-Carboxaldehyde | HCID 10256 | — |
| 반응물 | 2',5'-Dimethoxyacetophenone | HCID 70991 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-(2,5-Dimethoxyphenyl)-3-(indol-3-yl)-2-propen-1-one | HCID 54156913 | 44% |
반응 단계
2',5'-Dimethoxyacetophenone (1.80 g) and indole-3-carboxaldehyde (1.45 g) were dissolved in ethanol (20 ml), and piperidine (0.85 g) was added thereto, followed by heating under reflux for 72 hours. The precipitated crystals were collected by filtration, and the obtained crude crystals were recrystallized from ethanol to give Compound 89 (1.35 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952355 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-05fe39220067459285c6760684758e9b |
| 출처 메모 | uspto-grants-1999_09 |