Methyl 6-bromo-5-oxohexanoate → Methyl 4-(2-amino-1,3-thiazol-4-yl)butanoate

HRID 618134노트

반응식

HRID 618134 반응식
Br[CH2:2][C:3](=O)[CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8].[NH2:12][C:13]([NH2:15])=[S:14]>CCO>[NH2:15][C:13]1[S:14][CH:2]=[C:3]([CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8])[N:12]=1

참가 물질

4

반응물 2

HCID 582216Methyl 6-bromo-5-oxohexanoateHCID 2723790Thiourea

생성물 1

HCID 21699734Methyl 4-(2-amino-1,3-thiazol-4-yl)butanoate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Bromide 1-2 (3.45 g, 15.5 mmol) and thiourea (1.4 g, 18 mmol) were combined in 77 mL EtOH and heated to reflux. After disappearance of 1-2, the EtOH was removed by rotary evaporation and the residue was diluted with EtOAc, washed with water and brine, then dried (MgSO4), filtered and concentrated. The pH of the aqueous phase was adjusted to 7, and the solution was re-extracted with EtOAc (2×). These organic extracts were washed with brine, dried (MgSO4), filtered and concentrated, combined with the first organic residues, then purified by flash chromatography (silica, EtOAc) providing aminothiazole 1-3 as a white solid.

후처리

  1. temperatureheated to reflux
  2. customAfter disappearance of 1-2, the EtOH was removed by rotary evaporation
  3. additionthe residue was diluted with EtOAc
  4. washwashed with water and brine
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. concentrationconcentrated
  8. extractionthe solution was re-extracted with EtOAc (2×)
  9. washThese organic extracts were washed with brine
  10. dry with materialdried (MgSO4)
  11. filtrationfiltered
  12. concentrationconcentrated
  13. custompurified by flash chromatography (silica, EtOAc)

출처 및 근거

ORD 기록
ord-dc5f445633674670be2729c6bd3ceff5
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952306

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