Hydrochloric Acid → 2-(4-Methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride

HRID 618211노트

반응식

HRID 618211 반응식
[C:1]([CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:16])=[C:9]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:10]=1)#[N:2].[ClH:17].[CH2:18]([OH:20])[CH3:19]>ClCCl>[ClH:17].[CH2:18]([O:20][C:1](=[NH:2])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:16])=[C:9]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:10]=1)[CH3:19]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 18789597N-(5-cyanomethoxy-2-methylphenyl)-methanesulfonamide

생성물 1

HCID 693516472-(4-Methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(5-Cyanomethoxy-2-methylphenyl)-methanesulfonamide (3.48 g) was dissolved in a mixture of 70 ml of dichloromethane and 3.5 ml of ethanol. The reaction mixture was cooled in an ice bath, saturated with hydrogen chloride gas (Matheson, Newark, Calif.), and slowly allowed to come to room temperature and kept there for 16 hours. The solvent was evaporated leaving 5.2 g of 2-(4-methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride. ##STR67##

후처리

  1. customto come to room temperature
  2. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-3302d332e5f74bb29f9c07eca788ac0b
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952362

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