Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Glutamic Acid → [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Glutamic Acid | HCID 33032 | — |
| 반응물 | Methotrexate | HCID 126941 | — |
| 생성물 | [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid | HCID 70031183 | — |
반응 단계
The title compound was prepared by carboxypeptidase G cleavage of glutamic acid from methotrexate as described in the literature (J. Med. Chem. 24, 1450-1455 (1981)). The yield of I obtained was virtually quantitative.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952499 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-c57135597378462697ba70197b1c3f36 |
| 출처 메모 | uspto-grants-1999_09 |