Propylene Glycol → Amoxycillin 1,2-propanediolate

HRID 618632

반응식

HRID 618632 반응식
[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23].[CH2:26]([OH:30])[CH:27]([OH:29])[CH3:28]>ClCCl>[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23].[CH2:26]([O-:30])[CH:27]([O-:29])[CH3:28]

참가 물질

4

반응물 2

HCID 1030Propylene GlycolHCID 33613Amoxicillin

생성물 1

HCID 131721380Amoxycillin 1,2-propanediolate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Dichloromethane (63 ml; methanol-free) was added to amoxycillin trihydrate (3.5 g; purity by HPLC 86%; water 12.9%) with stirring at room temperature and, then, followed by the addition of 1,2-propanediol (22 ml). The reaction mixture was further stirred for about 20 min at the same temperature. The product was filtered and, then, washed on the filter with dichloromethane (100 ml). Thereafter, the product was suspended in dichloromethane (80 ml) and stirred for about 20 min at room temperature. The resulting suspension was filtered, washed on the filter with dichloromethane (100 ml) and, then, dried under vacuum overnight.

후처리

  1. stirringThe reaction mixture was further stirred for about 20 min at the same temperature
  2. filtrationThe product was filtered
  3. washwashed on the
  4. filtrationfilter with dichloromethane (100 ml)
  5. stirringstirred for about 20 min at room temperature
  6. filtrationThe resulting suspension was filtered
  7. washwashed on the
  8. filtrationfilter with dichloromethane (100 ml)
  9. customdried under vacuum overnight

출처 및 근거

ORD 기록
ord-e1185c721c3746e6995ee74ddb9cb0c1
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955458

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