Methyl butyrate → HCID 178456762, 화합물

HRID 618662

반응식

[CH3:1][C:2]1[N:11](COC(=O)C(C)(C)C)[C:10](=[O:20])[C:9]2[C:4](=[CH:5][C:6]([CH3:47])=[C:7]([CH:21]([N:23]([C:27]3[CH:46]=[CH:45][C:30]([C:31](OC4C(F)=C(F)C(F)=C(F)C=4F)=[O:32])=[CH:29][CH:28]=3)[CH2:24][C:25]#[CH:26])[CH3:22])[CH:8]=2)[N:3]=1.[NH2:48][C@@H:49]([CH2:54][CH2:55][C:56]1[NH:60][N:59]=[N:58][N:57]=1)[C:50]([O:52]C)=[O:51].C(OC)(=O)CCC>>[CH3:1][C:2]1[NH:11][C:10](=[O:20])[C:9]2[C:4](=[CH:5][C:6]([CH3:47])=[C:7]([CH:21]([N:23]([C:27]3[CH:28]=[CH:29][C:30]([C:31]([NH:48][CH:49]([CH2:54][CH2:55][C:56]4[NH:60][N:59]=[N:58][N:57]=4)[C:50]([OH:52])=[O:51])=[O:32])=[CH:45][CH:46]=3)[CH2:24][C:25]#[CH:26])[CH3:22])[CH:8]=2)[N:3]=1

참가 물질

반응물 3

HCID 12180Methyl butyrate

HCID 21847799HCID 21847799, 화합물

HCID 178501500methyl (2S)-2-amino-4-(1H-1,2,3,4-tetrazol-5-yl)butanoate

생성물 1

HCID 178456762HCID 178456762, 화합물

실험 절차

Using analogous procedures to those described in Example 1 pentafluorophenyl p-{N-[1-(2,7-dimethyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzoate was reacted with methyl (2S)-2-amino-4-(tetrazol-5-yl)butyrate and the resultant methyl butyrate was hydrolysed to give 2- {p-{N-[1-(2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzamido}-4-(tetrazol-5-yl)butyric acid in 25% yields m.p. 207° C.

출처 및 근거

ORD 기록: ord-aa05807e024d4971adce787a3e9ef0e8
출처 데이터셋: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05955463

연결된 노트

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