Ammonia → Tert-butyl 2-(aminomethyl)-2-ethylbutanoate

HRID 618747노트

반응식

HRID 618747 반응식
[C:1]([O:5][C:6](=[O:14])[C:7]([C:12]#[N:13])([CH2:10][CH3:11])[CH2:8][CH3:9])([CH3:4])([CH3:3])[CH3:2].N>C(O)C.[Ni]>[C:1]([O:5][C:6](=[O:14])[C:7]([CH2:12][NH2:13])([CH2:10][CH3:11])[CH2:8][CH3:9])([CH3:2])([CH3:4])[CH3:3]

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 54237674Tert-butyl 2-cyano-2-ethylbutanoate

생성물 1

HCID 54399069Tert-butyl 2-(aminomethyl)-2-ethylbutanoate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

29.21 g of 2-cyano-2-ethylbutyric acid tert-butyl ester, dissolved in 300 ml of ethanol, which contains 4% ammonia, are hydrogenated after normal pressure at 40° in the presence of 6 g of Raney nickel. After separating off from the catalyst, the batch is concentrated by evaporation in vacuo and the liquid that remains is distilled in vacuo to yield 2-aminomethyl-2-ethylbutyric acid tert-butyl ester, boiling point 65° at 0.6 mbar.

후처리

  1. customat 40°
  2. customAfter separating off from the catalyst
  3. concentrationthe batch is concentrated by evaporation in vacuo
  4. distillationthe liquid that remains is distilled in vacuo

출처 및 근거

ORD 기록
ord-48d2ab7a855b4de19421f2e34386267e
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955487

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