Ethyl phenylacetate → (4-Chlorosulfonyl-phenyl)-acetic acid ethyl ester

HRID 618760노트

반응식

HRID 618760 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[C:6]1([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[Cl:1][S:2]([C:9]1[CH:10]=[CH:11][C:6]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:8]=1)(=[O:5])=[O:3]

참가 물질

3

반응물 2

HCID 7590Ethyl phenylacetateHCID 24638Chlorosulfonic acid

생성물 1

HCID 10467900(4-Chlorosulfonyl-phenyl)-acetic acid ethyl ester

반응 조건

온도
40 °C

실험 절차

Chlorosulfonic acid (87 ml) was added dropwise to ethyl phenylacetate (48 g), and the mixture was stirred at 40° C. for 30 minutes. The reaction mixture was poured into ice water (1000 ml), and the separated oily substance was extracted with methylene chloride. The methylene chloride layer was washed successively with water and a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure gave ethyl 4-chlorosulfonylphenylacetate (42 g).

후처리

  1. extractionthe separated oily substance was extracted with methylene chloride
  2. washThe methylene chloride layer was washed successively with water
  3. dry with materiala saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate
  4. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-a8ab4aa416194c1dbdf66882f42980f9
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955505

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