Water → Methyl 4-(hydroxymethyl)cinnamate

HRID 618762노트

반응식

HRID 618762 반응식
[CH:1]([C:3]1[CH:14]=[CH:13][C:6]([CH:7]=[CH:8][C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1)=[O:2].[BH4-].[Na+].O>CO>[OH:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([CH:7]=[CH:8][C:9]([O:11][CH3:12])=[O:10])=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 53401287Methyl 3-(4-formylphenyl)-2-propenoate

생성물 1

HCID 54313853Methyl 4-(hydroxymethyl)cinnamate수율 93.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 4-formylcinnamate (5.58 g) in methanol (100 ml) was added sodium borohydride (0.4 g), and the mixture was stirred at room temperature for an hour. The reaction mixture was poured into water and extracted with methylene chloride. The methylene chloride layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure gave methyl 4-(hydroxymethyl)cinnamate (5.27 g).

후처리

  1. extractionextracted with methylene chloride
  2. washThe methylene chloride layer was washed with a saturated aqueous sodium chloride solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-854f17e8bcd54347b2d1d54c73847ac3
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955505

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