Hydroxyamine hydrochloride → 6-Fluoro-2,2-dimethyl-4-chromanone oxime

HRID 618811

반응식

HRID 618811 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([CH3:13])([CH3:12])[CH2:6][C:5]2=O.Cl.[NH2:16][OH:17]>CO.N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([CH3:13])([CH3:12])[CH2:6][C:5]2=[N:16][OH:17]

참가 물질

5

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 110632936-fluoro-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one

생성물 1

HCID 857577826-Fluoro-2,2-dimethyl-4-chromanone oxime

시약·촉매·용매 2

HCID 887Methanol용매HCID 1049Pyridine용매

실험 절차

By heating 10 mmol of 6-fluoro-2,2-dimethyl-4-chromanone with 12 mmol of hydroxylamine hydrochloride in 5 ml of methanol and 5 ml of pyridine for 2 hours to 80° C., after distilling off the solvent and precipitating with water, 6-fluoro-2,2-dimethyl-4-chromanone oxime is obtained; m.p. 108-110° C.

후처리

  1. distillationafter distilling off the solvent
  2. customprecipitating with water

출처 및 근거

ORD 기록
ord-9b8a42da1bf9488eaee2162c911c710f
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955607

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