Hydrazine hydrate (1:1) → 4-Hydrazinylpyridine-2-carbonitrile

HRID 61887

반응식

HRID 61887 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.O.[NH2:11][NH2:12]>O1CCOCC1.O>[C:8]([C:4]1[CH:3]=[C:2]([NH:11][NH2:12])[CH:7]=[CH:6][N:5]=1)#[N:9]

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 6933424-Chloro-2-pyridinecarbonitrile

생성물 1

HCID 629251564-Hydrazinylpyridine-2-carbonitrile

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

4-Chloro-2-cyanopyridine (1 g) was dissolved in hydrazine monohydrate (1 ml) and 1,4-dioxane (10 ml), and stirred overnight under reflux. The reaction solution was diluted with water (30 ml) and extracted repeatedly with ethyl acetate. The organic layer was concentrated to obtain the title compound as a crude product, which was used for the next step without further purification.

후처리

  1. temperatureunder reflux
  2. extractionextracted repeatedly with ethyl acetate
  3. concentrationThe organic layer was concentrated

출처 및 근거

ORD 기록
ord-930dc8f5cb434ba09836e381878fb8b4
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440922B2

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