Diisopropyl Ether → HCID 10563070, 화합물

HRID 619225노트

반응식

HRID 619225 반응식
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C:9]1[S:10][CH:11]=[C:12](/[C:14](=[N:18]/[O:19][C:20](=[O:22])[CH3:21])/[C:15]([OH:17])=[O:16])[N:13]=1.C(OC(C)C)(C)C>C(O)=O>[CH:1]([NH:8][C:9]1[S:10][CH:11]=[C:12](/[C:14](=[N:18]/[O:19][C:20](=[O:22])[CH3:21])/[C:15]([OH:17])=[O:16])[N:13]=1)=[O:3]

참가 물질

5

반응물 3

HCID 7914Diisopropyl EtherHCID 7918Acetic AnhydrideHCID 11241673(Z)-2-(Acetoxyimino)-2-(2-aminothiazol-4-yl)acetic acid

생성물 1

HCID 10563070HCID 10563070, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

To acetic anhydride (20.6 ml) was added formic acid (16.6 ml) at 15° C. The mixture was stirred at room temperature for 30 minutes. To the mixture was 2-(2-aminothiazol-4-yl)-2-(Z)-(acetoxyimino)acetic acid (10 g) under ice-cooling, and the reaction mixture was stirred at room temperature for 20 hours. To the mixture was added isopropyl ether (37.2 ml) under ice-cooling, and the mixture was stirred at the same temperature for 1 hour. The resulting precipitate was collected by filtration to give 2-(2-formylaminothiazol-4-yl)-2-(Z)-(acetoxyimino)acetic acid (9.39 g).

후처리

  1. temperaturecooling
  2. stirringthe reaction mixture was stirred at room temperature for 20 hours
  3. temperaturecooling
  4. stirringthe mixture was stirred at the same temperature for 1 hour
  5. filtrationThe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-bdd3d93c29894547a1c5f053388eec09
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05958914

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