Ethyl Acetate → 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)butan-1,3-dione

HRID 619292

반응식

[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11](=[O:13])[CH3:12])[C:5]=2[O:4][CH2:3][CH2:2]1.[H-].[Na+].[C:16](OCC)(=[O:18])[CH3:17]>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11](=[O:13])[CH2:12][C:16](=[O:18])[CH3:17])[C:5]=2[O:4][CH2:3][CH2:2]1

참가 물질

반응물 3

HCID 8857Ethyl Acetate

HCID 24758Sodium hydride

HCID 212680521-(2,3-Dihydro-1,4-benzodioxin-5-yl)ethanone

생성물 1

HCID 218462911-(2,3-Dihydro-1,4-benzodioxin-5-yl)butan-1,3-dione

반응 조건

온도: 80 °C

실험 절차

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-ethanone (1.2 g) was dissolved in 20 mL of ethyl acetate, and sodium hydride (0.33 g, 60% oil dispersion) was added. The reaction mixture was heated to 80° C. overnight, quenched with water, and neutralized with carbon dioxide to give an oily product of 1-(2,3-dihydro-1,4-benzodioxin-5-yl)butan-1,3-dione (0.37 g).

후처리

customquenched with water

출처 및 근거

ORD 기록: ord-b3584252cc8a4342b691132d71b2298f
출처 데이터셋: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05958934

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