Salicylic Acid → HCID 178455906, 화합물

HRID 61970

반응식

HRID 61970 반응식
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH3:11][CH2:12][C@@H:13]([C@H:15]([NH:176][C:177]([C@@H:179]([NH:187][C:188]([C@@H:190]([NH:195][C:196]([C@@H:198]([NH:206][C:207]([C@@H:209]([NH:213][C:214]([C@@H:216]([NH:218][C:219]([C@@H:221]([NH:227][C:228]([C@@H:230]([NH:236][C:237]([C@@H:239]([NH:245][C:246]([C@@H:248]([NH:253][C:254]([C@@H:256]([NH:262][C:263]([C@@H:265]([NH:271][C:272]([C@@H:274]([NH:277][C:278]([C@@H:280]([NH:285][C:286]([C@@H:288]([NH:293][C:294]([C@@H:296]([NH:299][C:300]([C@@H:302]([NH:306][C:307]([C@@H:309]([NH:317][C:318]([C@@H:320]([NH:324][C:325]([CH2:327][NH:328][C:329]([C@@H:331]([NH:337][C:338]([CH2:340][NH:341][C:342]([C@@H:344]([NH2:351])[CH2:345][C:346]1[NH:350][CH:349]=[N:348][CH:347]=1)=[O:343])=[O:339])[CH2:332][CH2:333][C:334]([OH:336])=[O:335])=[O:330])=[O:326])[C@H:321]([OH:323])[CH3:322])=[O:319])[CH2:310][C:311]1[CH:312]=[CH:313][CH:314]=[CH:315][CH:316]=1)=[O:308])[C@H:303]([OH:305])[CH3:304])=[O:301])[CH2:297][OH:298])=[O:295])[CH2:289][C:290]([OH:292])=[O:291])=[O:287])[CH2:281][CH:282]([CH3:284])[CH3:283])=[O:279])[CH2:275][OH:276])=[O:273])[CH2:266][CH2:267][CH2:268][CH2:269][NH2:270])=[O:264])[CH2:257][CH2:258][C:259]([NH2:261])=[O:260])=[O:255])[CH2:249][CH2:250][S:251][CH3:252])=[O:247])[CH2:240][CH2:241][C:242]([OH:244])=[O:243])=[O:238])[CH2:231][CH2:232][C:233]([OH:235])=[O:234])=[O:229])[CH2:222][CH2:223][C:224]([OH:226])=[O:225])=[O:220])[CH3:217])=[O:215])[CH:210]([CH3:212])[CH3:211])=[O:208])[CH2:199][CH2:200][CH2:201][NH:202][C:203]([NH2:205])=[NH:204])=[O:197])[CH2:191][CH:192]([CH3:194])[CH3:193])=[O:189])[CH2:180][C:181]1[CH:182]=[CH:183][CH:184]=[CH:185][CH:186]=1)=[O:178])[C:16]([NH:18][C@H:19]([C:25]([NH:27][C@H:28]([C:39]([NH:41][C@H:42]([C:47]([NH:49][C@H:50]([C:56]([NH:58][C@H:59]([C:110]([NH:112][CH2:113][C:114]([NH:116][CH2:117][C:118]([N:120]1[C@H:124]([C:125]([NH:127][C@H:128]([C:131]([NH:133][C@H:134]([C:137]([NH:139][CH2:140][C:141]([NH:143][C@H:144]([C:146]([N:148]2[C@H:152]([C:153]([N:155]3[C@H:159]([C:160]([N:162]4[C@H:166]([C:167]([NH:169][C@H:170]([C:173]([NH2:175])=[O:174])[CH2:171][OH:172])=[O:168])[CH2:165][CH2:164][CH2:163]4)=[O:161])[CH2:158][CH2:157][CH2:156]3)=[O:154])[CH2:151][CH2:150][CH2:149]2)=[O:147])[CH3:145])=[O:142])=[O:138])[CH2:135][OH:136])=[O:132])[CH2:129][OH:130])=[O:126])[CH2:123][CH2:122][CH2:121]1)=[O:119])=[O:115])=[O:111])[CH2:60][C:61]([NH:63][C@@H:64]1[O:69][C@H:68]([CH2:70][OH:71])[C@@H:67]([O:72][C@@H:73]2[O:78][C@H:77]([CH2:79][O:80][C@@:81]3([C:99]([OH:101])=[O:100])[O:86][C@@H:85]([CH2:87][C@H:88]([OH:93])[C@H:89]([OH:92])[CH2:90][OH:91])[C@H:84]([NH:94][C:95]([CH3:97])=[O:96])[C@@H:83]([OH:98])[CH2:82]3)[C@H:76]([OH:102])[C@H:75]([OH:103])[C@H:74]2[OH:104])[C@H:66]([OH:105])[C@H:65]1[NH:106][C:107]([CH3:109])=[O:108])=[O:62])=[O:57])[CH2:51][CH2:52][CH2:53][CH2:54][NH2:55])=[O:48])[CH2:43][CH:44]([CH3:46])[CH3:45])=[O:40])[CH2:29][C:30]1[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[NH:32][CH:31]=1)=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])[CH3:14].C([O-])(=O)C>C(#N)C.O>[CH3:11][CH2:12][C@@H:13]([C@H:15]([NH:176][C:177]([C@@H:179]([NH:187][C:188]([C@@H:190]([NH:195][C:196]([C@@H:198]([NH:206][C:207]([C@@H:209]([NH:213][C:214]([C@@H:216]([NH:218][C:219]([C@@H:221]([NH:227][C:228]([C@@H:230]([NH:236][C:237]([C@@H:239]([NH:245][C:246]([C@@H:248]([NH:253][C:254]([C@@H:256]([NH:262][C:263]([C@@H:265]([NH:271][C:272]([C@@H:274]([NH:277][C:278]([C@@H:280]([NH:285][C:286]([C@@H:288]([NH:293][C:294]([C@@H:296]([NH:299][C:300]([C@@H:302]([NH:306][C:307]([C@@H:309]([NH:317][C:318]([C@@H:320]([NH:324][C:325]([CH2:327][NH:328][C:329]([C@@H:331]([NH:337][C:338]([CH2:340][NH:341][C:342]([C@@H:344]([NH2:351])[CH2:345][C:346]1[NH:350][CH:349]=[N:348][CH:347]=1)=[O:343])=[O:339])[CH2:332][CH2:333][C:334]([OH:336])=[O:335])=[O:330])=[O:326])[C@H:321]([OH:323])[CH3:322])=[O:319])[CH2:310][C:311]1[CH:312]=[CH:313][CH:314]=[CH:315][CH:316]=1)=[O:308])[C@H:303]([OH:305])[CH3:304])=[O:301])[CH2:297][OH:298])=[O:295])[CH2:289][C:290]([OH:292])=[O:291])=[O:287])[CH2:281][CH:282]([CH3:284])[CH3:283])=[O:279])[CH2:275][OH:276])=[O:273])[CH2:266][CH2:267][CH2:268][CH2:269][NH2:270])=[O:264])[CH2:257][CH2:258][C:259]([NH2:261])=[O:260])=[O:255])[CH2:249][CH2:250][S:251][CH3:252])=[O:247])[CH2:240][CH2:241][C:242]([OH:244])=[O:243])=[O:238])[CH2:231][CH2:232][C:233]([OH:235])=[O:234])=[O:229])[CH2:222][CH2:223][C:224]([OH:226])=[O:225])=[O:220])[CH3:217])=[O:215])[CH:210]([CH3:211])[CH3:212])=[O:208])[CH2:199][CH2:200][CH2:201][NH:202][C:203]([NH2:205])=[NH:204])=[O:197])[CH2:191][CH:192]([CH3:194])[CH3:193])=[O:189])[CH2:180][C:181]1[CH:182]=[CH:183][CH:184]=[CH:185][CH:186]=1)=[O:178])[C:16]([NH:18][C@H:19]([C:25]([NH:27][C@H:28]([C:39]([NH:41][C@H:42]([C:47]([NH:49][C@H:50]([C:56]([NH:58][C@H:59]([C:110]([NH:112][CH2:113][C:114]([NH:116][CH2:117][C:118]([N:120]1[C@H:124]([C:125]([NH:127][C@H:128]([C:131]([NH:133][C@H:134]([C:137]([NH:139][CH2:140][C:141]([NH:143][C@H:144]([C:146]([N:148]2[C@H:152]([C:153]([N:155]3[C@H:159]([C:160]([N:162]4[C@H:166]([C:167]([NH:169][C@H:170]([C:173]([NH2:175])=[O:174])[CH2:171][OH:172])=[O:168])[CH2:165][CH2:164][CH2:163]4)=[O:161])[CH2:158][CH2:157][CH2:156]3)=[O:154])[CH2:151][CH2:150][CH2:149]2)=[O:147])[CH3:145])=[O:142])=[O:138])[CH2:135][OH:136])=[O:132])[CH2:129][OH:130])=[O:126])[CH2:123][CH2:122][CH2:121]1)=[O:119])=[O:115])=[O:111])[CH2:60][C:61]([NH:63][C@@H:64]1[O:69][C@H:68]([CH2:70][OH:71])[C@@H:67]([O:72][C@@H:73]2[O:78][C@H:77]([CH2:79][O:80][C@@:81]3([C:99]([OH:101])=[O:100])[O:86][C@@H:85]([CH2:87][C@H:88]([OH:93])[C@H:89]([OH:92])[CH2:90][OH:91])[C@H:84]([NH:94][C:95]([CH3:97])=[O:96])[C@@H:83]([OH:98])[CH2:82]3)[C@H:76]([OH:102])[C@H:75]([OH:103])[C@H:74]2[OH:104])[C@H:66]([OH:105])[C@H:65]1[NH:106][C:107]([CH3:109])=[O:108])=[O:62])=[O:57])[CH2:51][CH2:52][CH2:53][CH2:54][NH2:55])=[O:48])[CH2:43][CH:44]([CH3:45])[CH3:46])=[O:40])[CH2:29][C:30]1[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[NH:32][CH:31]=1)=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])[CH3:14].[C:1]([O-:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4]

참가 물질

4

반응물 2

HCID 338Salicylic Acid2회HCID 86674079CID 86674079

생성물 1

HCID 178455906HCID 178455906, 화합물

시약·촉매·용매 1

HCID 18373917Acetonitrile--water (1/1)용매2회

실험 절차

Salicylic acid (138.12 g/mol, 0.15 mg) 1.5 mg salicylic acid was dissolved in 100 μl ACN/H2O 50/50 mixture to give the mother solution. 10 μl of this latter solution were then added to 0.76 mg exendin-4 acetate dissolved in 50 μl ACN/H2O 50/50 followed by speedvac 2×1 hour as above at approximately 35° C., affording exendin-4 salicylate as a white solid.

후처리

  1. customto give the mother solution
  2. customfollowed by speedvac 2×1 hour as above at approximately 35° C.

출처 및 근거

ORD 기록
ord-a82eea5de7aa439dba4c27bf304e8613
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09445992B2

연결된 노트

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