Water → N1-[4-(5-isoquinolylsulfonyl)phenyl]acetamide

HRID 619718노트

반응식

HRID 619718 반응식
[CH:1]1[C:10]2[C:5](=[C:6]([S:11]([C:14]3[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=3)(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.O.[C:22](OC(=O)C)(=[O:24])[CH3:23]>N1C=CC=CC=1>[CH:1]1[C:10]2[C:5](=[C:6]([S:11]([C:14]3[CH:20]=[CH:19][C:17]([NH:18][C:22](=[O:24])[CH3:23])=[CH:16][CH:15]=3)(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 21846995HCID 21846995, 화합물

생성물 1

HCID 15435686N1-[4-(5-isoquinolylsulfonyl)phenyl]acetamide수율 44.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-(5-Isoquinolylsulfonyl)aniline 20 mg (0.1 mmol) was dissolved in a mixture solution of acetic anhydride 2 ml and pyridine 2 ml, the mixture was stirred overnight at room temperature, water was added to the reaction solution, and the solution was extracted with ethyl acetate. The organic layer was washed with saturated potassium hydrogensulfate and with saturated sodium hydrogencarbonate, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give N1-[4-(5-isoquinolylsulfonyl)phenyl]acetamide 10 mg (44.3%)

후처리

  1. extractionthe solution was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated potassium hydrogensulfate and with saturated sodium hydrogencarbonate
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ca7d9bb79b48448b8509309580b6ebee
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05959107

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