Hydrochloric Acid → 4-(3-Amino-2-oxopyrrolidine-1-ylmethyl)thiophene-2-carbonitrile hydrochloride

HRID 619837노트

반응식

HRID 619837 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]#[N:20])[S:16][CH:15]=2)[C:9]1=[O:21])(C)(C)C.[ClH:23]>CCOC(C)=O>[ClH:23].[NH2:7][CH:8]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:18]=[C:17]([C:19]#[N:20])[S:16][CH:15]=2)[C:9]1=[O:21]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 53990976[1-(5-Cyanothiophene-3-ylmethyl)-2-oxopyrrolidin-3-yl]carbamic acid tert-butyl ester

생성물 1

HCID 193510444-(3-Amino-2-oxopyrrolidine-1-ylmethyl)thiophene-2-carbonitrile hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

[1-(5-Cyanothiophene-3-ylmethyl)-2-oxopyrrolidin-3-yl]carbamic acid tert-butyl ester (4 g, 13.8 mmol) is added to a solution of 100 mL of EtOAc sat. with HCl gas at 0° C. After 3 hours, the solution is concentrated. The title compound (3.3 g, 13.5 mmol) is obtained as a white solid.

후처리

  1. concentrationthe solution is concentrated

출처 및 근거

ORD 기록
ord-61b3f509eb2546a3ae3cc5eb17f7c04f
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05958918

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