Hydrochloric Acid → 4-Methyl-1-naphthol

HRID 619872

반응식

HRID 619872 반응식
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12]C)=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1.Cl>>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 43814674-Methoxy-1-methylnaphthaleneHCID 10176127Pyridinium chloride

생성물 1

HCID 824834-Methyl-1-naphthol

반응 조건

온도
200 °C

실험 절차

4-Methyl-1-methoxynaphthalene (4) (145 g) was mixed with pyridine hydrochloride (250 g) and the mixture was heated at 200° C. for 3 hours. The mixture was cooled, treated with dilute hydrochloric acid, and extracted with ether. The ether extract was dried (MgSO4), filtered and the solvent removed, leaving a black oil which was extracted with petroleum b.p. 60°-80° C. (4×100 cm3). 4-Methyl-1-naphthol (5) was obtained as near colourless oily crystals which darken on storage.

후처리

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. extractionThe ether extract
  4. dry with materialwas dried (MgSO4)
  5. filtrationfiltered
  6. customthe solvent removed
  7. customleaving a black oil which
  8. extractionwas extracted with petroleum b.p. 60°-80° C. (4×100 cm3)

출처 및 근거

ORD 기록
ord-f30e9ede785445388d3e53904cba5691
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04818096

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