Phosphorus oxychloride → 2-Benzylthio-6,7-dichloro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine

반응식

[CH2:1]([S:8][C:9]1[N:20]=[C:12]2[N:13]=[C:14]([CH3:19])[C:15]([Cl:18])=[C:16](O)[N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:23])=O>>[CH2:1]([S:8][C:9]1[N:20]=[C:12]2[N:13]=[C:14]([CH3:19])[C:15]([Cl:18])=[C:16]([Cl:23])[N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 178432410HCID 178432410, 화합물

생성물 1

HCID 107822752-Benzylthio-6,7-dichloro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine수율 68%

실험 절차

This material was prepared in 68% yield from 2-benzylthio-6-chloro-7-hydroxy-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine and phosphorus oxychloride following the general procedure described in Example 20. The desired product was isolated as a solid, m.p. 103°-105° C. IR and 1H NMR spectra were in agreement with the assigned structure.

출처 및 근거

ORD 기록: ord-72b3130ae29f4a7587351a9338e3d0cc
출처 데이터셋: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04818273

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