Acetic Acid → Metosulam

HRID 619956

반응식

HRID 619956 반응식
[Na].[CH3:2][OH:3].[Cl:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=1[NH:13][S:14]([C:17]1[N:27]=[C:20]2[N:21]=[C:22](Cl)[CH:23]=[C:24](Cl)[N:19]2[N:18]=1)(=[O:16])=[O:15].[C:28]([OH:31])(=O)C>>[Cl:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=1[NH:13][S:14]([C:17]1[N:27]=[C:20]2[N:21]=[C:22]([O:31][CH3:28])[CH:23]=[C:24]([O:3][CH3:2])[N:19]2[N:18]=1)(=[O:16])=[O:15]

참가 물질

5

반응물 4

HCID 176Acetic AcidHCID 887MethanolHCID 5360545SodiumHCID 150175485,7-Dichloro-N-(2,6-dichloro-3-methylphenyl)[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide

생성물 1

HCID 86422Metosulam

실험 절차

Sodium (469 mg, 20.4 mmol) was added to 25 ml of methanol under nitrogen and allowed to react. The resulting solution was allowed to cool and then 2.14 g (5.0 mmol) of N-(2,6-dichloro-3-methylphenyl)-5,7-dichloro-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide were added with stirring. After about one hour, 1 ml of acetic acid was added and the mixture was poured into about 150 ml of ice water. The solid present was collected by filtration and dried to obtain 1.76 g (84.2 percent of theory) of the title compound as a white powder, m.p. 218°-221° C.

후처리

  1. customto react
  2. temperatureto cool
  3. filtrationThe solid present was collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-3a815746826a401cbb191ee9205a2cc9
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04818273

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