Chloroacetic Acid → 1-Benzyl-2-chloromethyl-1H-benzoimidazole

HRID 620029노트

반응식

HRID 620029 반응식
[CH2:1]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:16][CH2:17][C:18](O)=O>O>[CH2:1]([N:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:15]=[C:18]1[CH2:17][Cl:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 300Chloroacetic AcidHCID 2735482N1-Benzylbenzene-1,2-diamine

생성물 1

HCID 5634361-Benzyl-2-chloromethyl-1H-benzoimidazole수율 73.3%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

N-benzyl-o-phenylenediamine (3 g, 15 mmol), which is a known compound, was added to polyphosphoric ester (10 g), to which monochloroacetic acid (1.1 g, 12 mmol) was added and heated at 120° C. for 1 hour. Then water was added to the mixture to decompose remaining polyphosphoric ester. The resultant was refined in a conventional process and the title intermediate (2.25 g, 8.8 mmol) was obtained.

후처리

  1. additionwas added

출처 및 근거

ORD 기록
ord-4078903d91a04b40948dd88102af506c
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04818761

반응 노트

불러오는 중…