Chloroacetic Acid → 2-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

HRID 620034노트

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HRID 620034 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH:5]=[CH:6][CH:7]=1.[Cl:16][CH2:17][C:18](O)=O.C(=O)([O-])[O-].[Na+].[Na+]>O>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:15]=[C:18]2[CH2:17][Cl:16])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 300Chloroacetic AcidHCID 10340Sodium CarbonateHCID 21248421HCID 21248421, 화합물

생성물 1

HCID 212484162-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
130 °C

실험 절차

A mixture of N-(3-fluorophenyl)-o-phenylenediamine (0.8 g, 4 mmol) prepared in the preceding step (a), polyphosphoric ester (2.7 g) and monochloroacetic acid (0.4 g, 4.2 mmol) was heated for 1 hour at 130° C. and water was added to the reaction mixture to decompose an excess of polyphosphoric ester, then neutralized with sodium carbonate and the occurred oily substance was extracted with chloroform and the extract was washed, dried and concentrated in vacuo.

후처리

  1. extractionthe occurred oily substance was extracted with chloroform
  2. washthe extract was washed
  3. customdried
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c8562ea73a6143e88762b9fffa07ae2d
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04818761

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