Hydrochloric Acid → HCID 178468827, 화합물

HRID 620235노트

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HRID 620235 반응식
[C:1]([CH2:3][C:4]1[CH:14]=[CH:13][C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][CH:5]=1)#[N:2].C([Sn]([N:28]=[N+:29]=[N-:30])(CCCC)CCCC)CCC.Cl>COCCOC.CO>[NH:28]1[C:1]([CH2:3][C:4]2[CH:14]=[CH:13][C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][CH:5]=2)=[N:2][N:30]=[N:29]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 4984872Tributyltin azideHCID 11989373ethyl 4-(cyanomethyl)benzoate

생성물 1

HCID 178468827HCID 178468827, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 80711,2-Dimethoxyethane용매

반응 조건

온도
85 °C

실험 절차

Ethyl 4-cyanomethylbenzoate (approximately 8 g) was dissolved in DME (10 ml). The solution was added tris(n-butyl)tin azide (5 ml) and the resultant solution was stirred and heated at 85° C. overnight. The solution was cooled to room temperature. The cooled solution was diluted with methanol then acidified with 1N hydrochloric acid. The acidified mixture was stirred for one hour then partitioned between ethyl acetate and water. The organic layer was separated, dried over magnesium sulfate, filtered, and concentrated in vacuo.

후처리

  1. temperatureThe solution was cooled to room temperature
  2. customthen partitioned between ethyl acetate and water
  3. customThe organic layer was separated
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7a561e537421461a8231b4ad5f12dbd9
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04820723

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