Dimethylformamide → Ethyl 2-(3-nitrophenoxy)tetradecanoate

HRID 620697

반응식

HRID 620697 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:11]([O:13][C:14](=[O:29])[CH:15](Br)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:12].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>C(O)(=O)C.O>[CH2:11]([O:13][C:14](=[O:29])[CH:15]([O:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:12]

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 111373-NitrophenolHCID 11430Potassium CarbonateHCID 85791Tetradecanoic acid, 2-bromo-, ethyl ester

생성물 1

HCID 14122414Ethyl 2-(3-nitrophenoxy)tetradecanoate

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

A mixture of 250 g (1.79 mol) of m-nitrophenol, 602 g (1.79 mol) of Alphabromo-myristic acid ethyl ester, 248 g (1.79 mol) of potassium carbonate, and 1350 ml of dimethylformamide is heated to 80° C. for 3 h with stirring. The mixture is then poured out slowly into a mixture of 2300 ml of water and 250 ml of acetic acid. The product is extracted with dichloromethane. The solvent is removed by evaporation.

후처리

  1. extractionThe product is extracted with dichloromethane
  2. customThe solvent is removed by evaporation

출처 및 근거

ORD 기록
ord-8e1268a3ad914c10b3412d4df8d51779
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822729

연결된 노트

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