Acetic Anhydride → N-Acetoxyhexyl-1,2,3,4-tetrahydroquinoline

HRID 6207노트

반응식

HRID 6207 반응식
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[C:17]2[CH:12]([CH2:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1.[C:18](OC(=O)C)(=[O:20])[CH3:19].C(N(CC)CC)C>ClCCl>[C:18]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1)(=[O:20])[CH3:19]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 67859558N-hydroxyhexyltetrahydroquinoline

생성물 1

HCID 53737711N-Acetoxyhexyl-1,2,3,4-tetrahydroquinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 233.4 g (1 mole) of N-hydroxyhexyltetrahydroquinoline and 153.1 g (1.5 moles) of acetic anhydride in dichloromethane are added 151.8 g (1.5 moles) of triethylamine and 8.5 g (1 mole %) of 4-N,N-dimethylaminopyridine, and the reaction is stirred at room temperature for 3 hours. The product solution is washed with cold 2N HCl followed by saturated sodium bicarbonate, and the organic layer is filtered through cotton and evaporated.

후처리

  1. washThe product solution is washed with cold 2N HCl
  2. filtrationthe organic layer is filtered through cotton
  3. customevaporated

출처 및 근거

ORD 기록
ord-bf199b56f7eb4319ac3c695eb26223f8
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05247042

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