Sodium Iodide → 4(1H)-Pyridinone, 1,5-bis(diphenylmethoxy)-2-(hydroxymethyl)-

HRID 620750노트

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HRID 620750 반응식
[OH:1][N:2]1[CH:7]=[C:6]([O:8][CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5](=[O:22])[CH:4]=[C:3]1[CH2:23][OH:24].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].[CH:33](Cl)([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>CS(C)=O>[CH:33]([O:1][N:2]1[CH:7]=[C:6]([O:8][CH:9]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5](=[O:22])[CH:4]=[C:3]1[CH2:23][OH:24])([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 7035ChlorodiphenylmethaneHCID 11430Potassium CarbonateHCID 143063884(1H)-Pyridinone, 5-(diphenylMethoxy)-1-hydroxy-2-(hydroxyMethyl)-

생성물 1

HCID 117521734(1H)-Pyridinone, 1,5-bis(diphenylmethoxy)-2-(hydroxymethyl)-수율 100%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

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온도
100 °C

실험 절차

8.1 g (0.0251 mol) of the product of Step (2) was added to dimethylsulfoxide (125 ml) and heated to 100° C. and dissolved. After cooling the solution to room temperature, 5.2 g (0.0375 mol) of potassium carbonate and 5.6 g (0.0375 mol) of sodium iodide and 6.7 ml (0.0375 mol) of benzhydrylchloride were added thereto, and the mixture was reacted at room temperature for 18 hours under stirring. To the reaction solution, ice water was gradually added, and formed precipitates were collected by filtration, washed sequentially with water and ethyl ether/n-hexane (2/1), and dried to obtain 12.3 g (yield: 100%) of the above identified compound.

후처리

  1. dissolutiondissolved
  2. temperatureAfter cooling the solution to room temperature
  3. customthe mixture was reacted at room temperature for 18 hours
  4. customformed
  5. customprecipitates
  6. filtrationwere collected by filtration
  7. washwashed sequentially with water and ethyl ether/n-hexane (2/1)
  8. customdried
  9. customto obtain 12.3 g (yield: 100%) of the

출처 및 근거

ORD 기록
ord-6e75ba8a6cd64955a2afbfdd15dcfa17
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822786

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