Hydrochloric Acid → 4-(2-Hydroxyiminopropionyl)pyridine
반응식
[N:1](OCCC(C)C)=[O:2].C[O-].[Na+].[C:12]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)(=[O:15])[CH2:13][CH3:14].Cl>CO>[OH:2][N:1]=[C:13]([CH3:14])[C:12]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[O:15]참가 물질
6
실험 절차
To a solution of isoamyl nitrite (2.6 ml) and sodium methoxide (28% in methanol, 3.4 ml) in methanol (40 ml) was added dropwise a solution of 4-propionylpyridine (2.0 g) in methanol (10 ml) under ice-cooling. The reaction mixture was stirred at ambient temperature for 3 hours, and then neutralized with 1N hydrochloric acid. After evaporation to remove methanol, the organic layer was extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate, evaporated and triturated with diisopropyl ether to give 4-(2-hydroxyiminopropionyl)pyridine (0.95 g).
후처리
- temperaturecooling
- customAfter evaporation
- customto remove methanol
- extractionthe organic layer was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
- customtriturated with diisopropyl ether
출처 및 근거
- ORD 기록
- ord-bb0d01142a9a4ba7b76eacf480d5f933
- 출처 데이터셋
- uspto-grants-1989_04
- 특허 번호
- US04822805
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