Potassium Carbonate → 2-(2-Fluorophenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole

HRID 620839노트

반응식

HRID 620839 반응식
[OH:1][N:2]=[C:3]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)[C:4]([CH3:6])=O.[F:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH:16]=O.C([O-])(=O)C.[NH4+:26].C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C.O>[F:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[C:16]1[N:2]([OH:1])[C:3]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[C:4]([CH3:6])[N:26]=1

참가 물질

7

반응물 4

HCID 11430Potassium CarbonateHCID 67970o-FluorobenzaldehydeHCID 517165Ammonium AcetateHCID 737518861-Hydroxyimino-1-(3-pyridyl)acetone

생성물 1

HCID 103332812-(2-Fluorophenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole수율 28%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

To a solution 1-hydroxyimino-1-(3-pyridyl)acetone (0.5 g) in acetic acid (10 ml) was added 2-fluorobenzaldehyde (0.76 g) and ammonium acetate (2.35 g), and refluxed for 30 minutes. Then, the solution was poured into water (75 ml), neutrallized with aqueous potassium carbonate, and extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated, and the residue was triturated with diisopropyl ether to give 2-(2-fluorophenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole (0.23 g).

후처리

  1. temperaturerefluxed for 30 minutes
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customthe residue was triturated with diisopropyl ether

출처 및 근거

ORD 기록
ord-70513545ded44daea38c5ae6eea9060e
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822805

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