Hydrochloric Acid → 1,2,3,9-Tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-9-methyl-4H-carbazol-4-one hydrochloride monohydrate

HRID 621205

반응식

HRID 621205 반응식
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][CH:8]1[C:20](=[O:21])[C:19]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH3:22])[C:11]=2[CH2:10][CH2:9]1.[ClH:23]>>[OH2:21].[ClH:23].[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][CH:8]1[C:20](=[O:21])[C:19]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH3:22])[C:11]=2[CH2:10][CH2:9]1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 172316GR 67330

생성물 1

HCID 142338961,2,3,9-Tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-9-methyl-4H-carbazol-4-one hydrochloride monohydrate

실험 절차

A suspension of 1,2,3,9-tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-9-methyl-4H-carbazol-4-one (20 g) in IMS (200 ml) was heated to boiling and 2N hydrochloric acid (50 ml) was added. The resulting solution was allowed to cool to 20°, the resultant suspension was stirred for 1 h and then cooled at 4° for 2 h. The product was filtered off and dried in vacuo at 55° to yield the title compound (20.8 g), m.p. 290° (decomp.).

후처리

  1. additionwas added
  2. temperatureto cool to 20°
  3. temperaturecooled at 4° for 2 h
  4. filtrationThe product was filtered off
  5. customdried in vacuo at 55°

출처 및 근거

ORD 기록
ord-b455832453d7436d8de163e6b5fca260
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822881

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