Hydrochloric Acid → HCID 178444387, 화합물

HRID 621396

반응식

HRID 621396 반응식
Cl.[CH2:2]([C@H:7]1[CH2:12][CH2:11][C@H:10]([C:13]([NH2:15])=[NH:14])[CH2:9][CH2:8]1)[CH2:3][CH2:4][CH2:5][CH3:6].[CH3:16][O:17][CH:18]([C:23](OC)=[O:24])[C:19](OC)=[O:20].C[O-].[Na+].Cl>CO>[CH2:2]([C@H:7]1[CH2:8][CH2:9][C@H:10]([C:13]2[N:15]=[C:23]([OH:24])[C:18]([O:17][CH3:16])=[C:19]([OH:20])[N:14]=2)[CH2:11][CH2:12]1)[CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 78718Dimethyl methoxymalonateHCID 10942334Sodium MethoxideHCID 178444523HCID 178444523, 화합물

생성물 1

HCID 178444387HCID 178444387, 화합물수율 76.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

This trans-4-pentylcyclohexanecarboxamidine hydrochloride (69 g, 0.30 mol) and dimethyl methoxymalonate (48 g, 0.30 mol) were added to a solution of sodium methylate (56 g, 1.0 mol) dissolved in anhydrous methanol (1 l), followed by heating the mixture under reflux with stirring for 5 hours, thereafter cooling the resulting material, mixing it with 6N-hydrochloric acid (500 ml), agitating the mixed liquid at room temperature for 20 minutes, filtering the liquid under suction through a filter, washing the resulting residue on the filter with water and methanol and drying it under reduced pressure to obtain 2-(trans-4-pentylcyclohexyl)-4,6-dihydroxy-5-methoxypyrimidine (67 g, 0.23 mol).

후처리

  1. temperatureby heating the mixture
  2. temperatureunder reflux
  3. temperaturecooling the resulting material
  4. stirringagitating the mixed liquid at room temperature for 20 minutes
  5. filtrationfiltering the liquid under suction through a filter
  6. washwashing the resulting residue on the
  7. filtrationfilter with water and methanol
  8. customdrying it under reduced pressure

출처 및 근거

ORD 기록
ord-75d317e262074094992716415ffca4bd
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824596

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