Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl isothiocyanate → N-Methyl-N'-(4,4-dimethyl-1,2,3,4-tetrahydro-1,3-dioxo-7-isoquinolinyl)-thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl isothiocyanate | HCID 11167 | — |
| 반응물 | 7-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dione | HCID 13558151 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | N-Methyl-N'-(4,4-dimethyl-1,2,3,4-tetrahydro-1,3-dioxo-7-isoquinolinyl)-thiourea | HCID 21242849 | — |
반응 단계
1.3 g. (6.3 mmol) 7-Amino-4,4-dimethyl-isoquinolin-1,3-dione were dissolved in 30 ml. chloroform, mixed with 1.4 g. methyl isothiocyanate and boiled under reflux for 6 hours. The reaction mixture was then cooled and the precipitate was filtered off with suction and recrystallised from ethanol. Yield: 0.8 g. (46% of theory); m.p. 206°-207° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04824835 |
| 출처 데이터셋 | uspto-grants-1989_04 |
| ORD ID | ord-92272c8f848e4bf7884f58dfbe690085 |
| 출처 메모 | uspto-grants-1989_04 |