Acetic Anhydride → HCID 21243163, 화합물

HRID 621425

반응식

HRID 621425 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH:9][CH:10]2[CH2:12][CH2:11]2)[N:3]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>O1CCCC1>[CH:10]1([NH:9][C:4]2[N:3]=[C:2]([NH:1][C:20](=[O:22])[CH3:21])[N:7]=[C:6]([NH2:8])[N:5]=2)[CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 47866Cyromazine

생성물 1

HCID 21243163HCID 21243163, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a suspension of 49.8 g of 2,4-diamino-6-cyclopropylamino-1,3,5-triazine and 45.5 g of triethylamine in 1200 ml of tetrahydrofuran are slowly added dropwise, at about 60° C. (in about 6 hours), 31.7 g of acetic acid anhydride dissolved in 100 ml of tetrahydrofuran. The reaction mixture is subsequently refluxed for 18 hours, filtered hot and then concentrated by evaporation until crystallisation commences. After the addition of about 300 ml of diethyl ether, the product if filtered off as white crystalline powder. It has a melting point of 190°-195° C.

후처리

  1. temperatureThe reaction mixture is subsequently refluxed for 18 hours
  2. filtrationfiltered hot
  3. concentrationconcentrated by evaporation until crystallisation commences
  4. additionAfter the addition of about 300 ml of diethyl ether
  5. filtrationthe product if filtered off as white crystalline powder

출처 및 근거

ORD 기록
ord-6b903e07e5bc49d982a83da5f239842c
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824845

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