1,3-Cyclohexanedione → Benzonitrile, 2-((3-oxo-1-cyclohexen-1-yl)amino)-
반응식
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:10]1(=O)[CH2:15][CH2:14][CH2:13][C:12](=[O:16])[CH2:11]1>O.O.CC1C=CC(S(O)(=O)=O)=CC=1>[O:16]=[C:12]1[CH2:13][CH2:14][CH2:15][C:10]([NH:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])=[CH:11]1참가 물질
5
실험 절차
A mixture of 2-aminobenzonitrile (120 g) and 1,3-cyclohexandione (120 g) in water (400 ml) was heated to 40° and 4-methylbenzenesulfonic acid monohydrate (6.2 g) was added, with stirring. The mixture was stirred at 40° for 1 hr. The mixture was filtered, and the filter cake was washed with water to provide 200 g (93%) of 2-(3-oxocyclohexen-1-yl)aminobenzonitrile, mp 191.4°.
후처리
- temperaturewas heated to 40°
- stirringThe mixture was stirred at 40° for 1 hr
- filtrationThe mixture was filtered
- washthe filter cake was washed with water
출처 및 근거
- ORD 기록
- ord-695590d38ba04361a966067c6963981f
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05247091
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