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Hydrochloric Acid → 2-(4-Chlorophenyl)-N-[4-(dimethylamino)phenyl]-N-methyl-3H-imidazo[4,5-b]pyridine-3-acetamide hydrochloride hydrate

HRID 622005
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인쇄 미리보기

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HRID 622005 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([N:20]([C:22]3[CH:27]=[CH:26][C:25]([N:28]([CH3:30])[CH3:29])=[CH:24][CH:23]=3)[CH3:21])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Cl.C(OC(C)C)(C)C>C(O)(C)C>[OH2:19].[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([N:20]([C:22]3[CH:23]=[CH:24][C:25]([N:28]([CH3:30])[CH3:29])=[CH:26][CH:27]=3)[CH3:21])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 143903702-(4-Chlorophenyl)-N-[4-(dimethylamino)phenyl]-N-methyl-3H-imidazo [4,5-b]pyridine-3-acetamide

생성물 1

HCID 230374202-(4-Chlorophenyl)-N-[4-(dimethylamino)phenyl]-N-methyl-3H-imidazo[4,5-b]pyridine-3-acetamide hydrochloride hydrate수율 118.6%

시약·촉매·용매 1

HCID 3776
Isopropanol
용매
2회

실험 절차

A solution of 2-(4-chlorophenyl)-N-[4-(dimethylamino)phenyl]-N-methyl-3H-imidazol[4.5-b]pyridine-3-acetamide (5.6 g, 0.0133 mole) in hot isopropyl alcohol was acidified with hydrogen chloride in isopropyl alcohol. Isopropyl ether was added to precipitate a solid. The solid was collected by filtration, rinsed with isopropyl ether, and dried under high vacuum to give 3.74 g (52%) of title compound, mp 120°-132° C. (shrinks), 150°-155° C. (melts).

후처리

  1. customto precipitate a solid
  2. filtrationThe solid was collected by filtration
  3. washrinsed with isopropyl ether
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-a37944a321004104a9ceddb1af56b11c
출처 데이터셋
uspto-grants-1989_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04824951

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