Hydrochloric Acid → 2-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride

HRID 622426노트

반응식

HRID 622426 반응식
P(=[S:5])([O-])([O-])[O-].[Na+].[Na+].[Na+].Cl.[C:10]([O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[NH:23])[CH2:21][Cl:22])[CH2:16][CH2:15]1)(=[O:12])[NH2:11].Cl>O>[ClH:22].[C:10]([O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[NH:23])[CH2:21][SH:5])[CH2:16][CH2:15]1)(=[O:12])[NH2:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 9877537Trisodium thiophosphateHCID 212930032-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride

생성물 1

HCID 212929412-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride수율 97.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4.95 g of trisodium phosphorothioate were added to an ice-cooled solution of 6.40 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride in 32 ml of water, and the mixture was stirred at room temperature for 2.5 hours. 28 ml of 1N hydrochloric acid were then added, and the mixture was heated at 60° C. for 30 minutes. The reaction mixture was worked up in the same manner as in Example 1(2), giving 6.20 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride.

후처리

  1. temperaturethe mixture was heated at 60° C. for 30 minutes

출처 및 근거

ORD 기록
ord-28b83350812a47d291f101b3e858f52d
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04771046

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